The three Rs and biomedical research.

Editorial Staff Assistant Managing Editor: Dawn McCoy Senior Editors: Eleanore Butz, R. Brooks Hanson, Pamela J. Hines, Barbara Jasny, Katrina L. Kelner, Paula A. Kiberstis, Linda J. Miller, L. Bryan Ray, Phillip D. Szuromi, David F. Voss Associate Editors: Gilbert J. Chin, Suki Parks, Linda R. Rowan Letters: Christine Gilbert, Editor; Steven S. Lapham, Assistant Letters Editor, Charlene King, Assistant Book Reviews: Katherine Livingston, Editor, Jeffrey Hearn, Editorial Assistant Editing: Valerie Jablow, Supervisor, Cara Tate, Senior Copy Editor; Jeffrey E. Cook, Harry Jach, Erik G. Morris, Christine M. Pearce Copy Desk: Ellen E. Murphy, Supervisor; Sherri Byrand, Joi S. Granger, Beverly Shields, Kameaka Williams, Assistant Editorial Support: Carolyn Kyle, Editorial Assistant, Josh Lipicky, Michele Listisard, Diane Long, Patricia M. Moore, Ted Smith, Manuscript Assistants Administrative Support: Sylvia Kihara, Brent Gendleman Computer Specialist: Roman Frillarte